Newport Beach Neurologists

Miscellaneous Agents

1. NONSTEROIDAL ANTI-INFLAMMATORY AGENTS (NSAIDs)

   Naproxen, ibuprofen, and other NSAIDs have been tried for migraine prevention. Their clinical efficacy is not as good as beta blockers, valproate, or calcium channel blockers. The potential side effects, such as stomach upset, make them inappropriate for long-term therapy. However, for short-term or "mini-prophylaxis," particularly for menstrual migraine, agents such as naproxen sodium (Naprosyn), may be very effective.

2. MAGNESIUM

   Even though magnesium deficiency in the brain is implicated in the causation of migraine, there is still no proof that magnesium replacement is of any benefit in migraine prophylaxis.

3. RIBOFLAVIN

   In recent studies, riboflavin, in a dosage of 200 mg. twice a day, was shown to reduce significantly the frequency of migraine, as compared to placebo. Its mechanism of action is unknown.