Naproxen, ibuprofen, and other NSAIDs have been tried for migraine prevention. Their clinical efficacy is not as good as beta blockers, valproate, or calcium channel blockers. The potential side effects, such as stomach upset, make them inappropriate for long-term therapy. However, for short-term or "mini-prophylaxis," particularly for menstrual migraine, agents such as naproxen sodium (Naprosyn), may be very effective.
Even though magnesium deficiency in the brain is implicated in the causation of migraine, there is still no proof that magnesium replacement is of any benefit in migraine prophylaxis.
In recent studies, riboflavin, in a dosage of 200 mg. twice a day, was shown to reduce significantly the frequency of migraine, as compared to placebo. Its mechanism of action is unknown.
Newport Beach Neurologists specializes in the treatment of pain, severe chronic headache, and multiple sclerosis.
Our guiding philosophy is that pain can stem from the body, the mind, or both. Thus, we are structured as an integrative entity equipped with all resources-medical, psychiatric, and psychological-to help patients manage pain and multiple sclerosis.